Cov neeg mob raum mob ntev (CKD) feem ntau muaj hyperphosphatemia, thiab hyperphosphatemia ntev tuaj yeem ua rau muaj teeb meem loj xws li hyperparathyroidism theem nrab, raum osteodystrophy, thiab kab mob plawv. Kev tswj cov ntshav phosphorus qib yog ib feem tseem ceeb ntawm kev tswj cov neeg mob CKD, thiab phosphate binders yog lub hauv paus tseem ceeb tshuaj rau kev kho mob hyperphosphatemia. Nyob rau hauv xyoo tas los no,lanthanum carbonate, raws li hom tshiab uas tsis yog-calcium thiab non-aluminium phosphate binder, tau maj mam nkag mus rau tib neeg lub zeem muag thiab pib "kev sib tw" nrog cov tshuaj phosphate binders.
Cov "merits" thiab "demerits" ntawm tsoos phosphate binders
Cov tshuaj phosphate binders feem ntau suav nrog calcium uas muaj phosphate binders (xws li calcium carbonate thiab calcium acetate) thiab aluminium-muaj phosphate binders (xws li aluminium hydroxide). Lawv ua ke nrog phosphates hauv cov khoom noj los tsim cov tshuaj insoluble, yog li txo cov plab hnyuv nqus ntawm phosphorus.
Calcium-muaj phosphate binders: Tus nqi qis thiab txo cov phosphorus-txo cov nyhuv, tab sis kev siv mus ntev yuav ua rau hypercalcemia thiab ua rau muaj kev pheej hmoo ntawm vascular calcification.
Aluminium-muaj phosphorus binders: Muaj zog phosphorus txo cov nyhuv, tab sis aluminium tsub zuj zuj yog lom heev thiab tuaj yeem ua rau cov kab mob txhuas ntsig txog pob txha thiab encephalopathy, thiab tam sim no siv tsawg dua.
Lanthanum carbonate: Cov neeg tuaj tshiab nce, nrog cov txiaj ntsig zoo
Lanthanum carbonate yog cov carbonate ntawm cov hlau tsis tshua muaj hauv ntiaj teb lanthanum, nrog rau cov phosphorus khi mechanism. Nws tso tawm lanthanum ions nyob rau hauv ib puag ncig acidic ntawm lub plab zom mov thiab tsim cov lanthanum phosphate heev insoluble nrog phosphate, yog li tiv thaiv kev nqus ntawm phosphorus.
Cov lus qhia luv luv ntawm lanthanum carbonate
| Khoom npe | Lanthanum carbonate |
| Formula | La2(CO3)3.xH2O |
| CAS Nr. | 6487-39-4 |
| Molecular Luj | 457.85 (hli) |
| Qhov ntom | 2.6g / cm3 |
| Melting point | N/A |
| Qhov tshwm sim | Dawb crystal hmoov |
| Solubility | Soluble nyob rau hauv dej, me ntsis soluble nyob rau hauv muaj zog mineral acids |
| Kev ruaj ntseg | Yooj yim hygroscopic |
Piv nrog cov tshuaj phosphorus binders, lanthanum carbonate muaj qhov zoo hauv qab no:
Tsis muaj calcium thiab txhuas, kev nyab xeeb dua: Tsis txhob muaj kev pheej hmoo ntawm hypercalcemia thiab aluminium lom, tshwj xeeb tshaj yog rau cov neeg mob uas muaj kev kho mob ntev thiab kev pheej hmoo ntawm vascular calcification.
Muaj zog phosphorus binding muaj peev xwm, tseem ceeb phosphorus txo cov nyhuv: Lanthanum carbonate tuaj yeem khi phosphorus zoo nyob rau hauv ntau qhov pH, thiab nws lub peev xwm binding muaj zog dua li cov tshuaj phosphorus binders.
Tsawg qhov tsis zoo ntawm plab hnyuv, ua raws li tus neeg mob zoo: Lanthanum carbonate saj zoo, yooj yim rau noj, muaj me ntsis plab hnyuv, thiab cov neeg mob feem ntau yuav ua raws li kev kho mob mus sij hawm ntev.
Kev tshawb fawb pov thawj: Lanthanum carbonate ua tau zoo
Ntau qhov kev tshawb fawb soj ntsuam tau lees paub qhov ua tau zoo thiab kev nyab xeeb ntawm lanthanum carbonate hauv cov neeg mob CKD. Cov kev tshawb fawb tau pom tias lanthanum carbonate tsis qis dua lossis txawm tias zoo dua rau cov tshuaj phosphate binders hauv kev txo cov ntshav phosphorus, thiab tuaj yeem tswj hwm qib iPTH zoo thiab txhim kho cov pob txha metabolism. Tsis tas li ntawd, kev nyab xeeb ntawm kev kho mob mus sij hawm ntev nrog lanthanum carbonate yog qhov zoo, thiab tsis muaj qhov pom tseeb ntawm lanthanum tsub zuj zuj thiab cov tshuaj lom neeg tau pom.
Kev kho tus kheej: Xaiv txoj kev npaj zoo tshaj plaws rau tus neeg mob
Txawm hais tias lanthanum carbonate muaj ntau qhov zoo, nws tsis tau txhais hais tias nws tuaj yeem hloov cov tshuaj phosphate binders. Txhua cov tshuaj muaj nws cov indications thiab contraindications, thiab cov kev kho mob yuav tsum yog tus kheej raws li qhov xwm txheej ntawm tus neeg mob.
Lanthanum carbonate yog qhov tsim nyog rau cov neeg mob hauv qab no:
Cov neeg mob uas muaj hypercalcemia lossis kev pheej hmoo ntawm hypercalcemia
Cov neeg mob uas muaj vascular calcification lossis kev pheej hmoo ntawm vascular calcification
Cov neeg mob uas tsis zoo siab ntev los yog ua tsis tau zoo ntawm cov tshuaj phosphate binders
Cov tshuaj phosphate binders tseem tuaj yeem siv rau cov neeg mob hauv qab no:
Cov neeg mob uas muaj kev lag luam tsawg
Cov neeg mob uas tsis haum los yog intolerant ntawm lanthanum carbonate
Saib rau yav tom ntej: Lanthanum carbonate muaj lub neej yav tom ntej
Nrog rau qhov tob ntawm kev tshawb fawb soj ntsuam thiab kev sib sau ntawm kev soj ntsuam kev paub, cov xwm txheej ntawm lanthanum carbonate hauv kev kho mob hyperphosphatemia hauv cov neeg mob CKD yuav txuas ntxiv txhim kho. Nyob rau hauv lub neej yav tom ntej, lanthanum carbonate yuav tsum yog thawj kab phosphate binder, coj xov xwm zoo rau ntau tus neeg mob CKD.
Post lub sij hawm: Mar-25-2025